Background Astragalus polysaccharide (APS) is a key active ingredient isolated from
Astragalus membranaceus that has been reported to be a potential treatment for obesity and …

Obesity causes insulin resistance, and PPARγ ligands such as rosiglitazone are insulin
sensitizing, yet the mechanisms remain unclear. In C57BL/6 (B6) mice, obesity induced by a …

Introduction Abdominal obesity increases the risk of developing ovarian cancer but the
molecular mechanisms of how obesity supports ovarian cancer development remain …

Background Chronic inflammation is associated with increased bone resorption and is
linked to osteopenia, or low bone mass. Obesity is also associated with low-grade chronic …

Background Obesity is a major risk factor for metabolic syndrome and a serious health
concern worldwide. Various strategies exist to treat and prevent obesity, including dietary …

Background Insulin resistance (IR) complicates chronic kidney disease (CKD). We tested the
hypothesis that CKD activates a broad reflex response from the kidneys and the white …

Design: Female weanling rats (post-natal day 21, n= 105) were fed a low fat/low salt diet,
low fat/high salt diet, high fat/low salt diet or a high salt/high fat diet for 24 days. Metabolic …

Objective Excess dietary fat and sodium (NaCl) are both associated with obesity and
metabolic dysfunction. In mice, high NaCl has been shown to block high‐fat (HF) diet …

Consumption of a high-fat diet (HFD) promotes the development of obesity, a disease
resulting from an imbalance between energy intake and energy expenditure. Brown adipose …

The versatility of the intrarenal immunologic micromilieu through dietary modification and the
subsequent effects on susceptibility to ischemic acute kidney injury (AKI) are unclear. We …