Neurotransmitters are considered as a fundamental regulator in the process of neuronal
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …

Convergent data, across species, paint a compelling picture of the critical role of the gut and
its resident microbiota in several brain functions and disorders. The chemicals mediating …

Background Ovarian follicle development plays an important role in determination of poultry
egg production. The follicles at the various developmental stages possess their own distinct …

The triggers of status epilepticus (SE) in non-epileptic patients can vary widely, from
idiopathic causes to exposure to chemoconvulsants. Regardless of its etiology, prolonged …

Neuroactive steroids (NASs) have potent anxiolytic, anticonvulsant, sedative, and hypnotic
actions, that reflect in part their efficacy as GABA AR positive allosteric modulators (PAM). In …

Zinc ions (Zn2+) are concentrated in various brain regions and can act as a neuromodulator,
targeting a wide spectrum of postsynaptic receptors and enzymes. Zn2+ inhibits the …

Agonists are ligands that bind to receptors and activate them. In the case of ligand-gated ion
channels, such as the muscle-type nicotinic acetylcholine receptor, mechanisms of agonist …

Allopregnanolone is an endogenous neurosteroid that acts in a rapid non-genomic manner
to enhance the function of the GABA A receptor (GABA AR), the major inhibitory receptor in …

The recent approval of formulations of the endogenous neurosteroid allopregnanolone
(brexanolone) and the synthetic neuroactive steroid SAGE-217 (zuranolone) to treat …

The GABA type A receptor (GABAAR) belongs to the family of pentameric ligand-gated ion
channels and plays a key role in inhibition in adult mammalian brains. Dysfunction of this …