Cirrhosis is an important cause of morbidity and mortality in people with chronic liver
disease worldwide. In 2019, cirrhosis was associated with 2.4% of global deaths. Owing to …

The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

Background Combating viral hepatitis is part of the UN Sustainable Development Goals
(SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector …

Background Accurate data on type 1 diabetes prevalence, incidence, associated mortality
and life expectancy are crucial to inform public health policy, but these data are scarce. We …

We assembled an ancestrally diverse collection of genome-wide association studies
(GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls …

Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Depression rates in young people have risen sharply in the past decade, especially in
females, which is of concern because adolescence is a period of rapid social, emotional …

Rheumatoid arthritis (RA) is a systemic autoimmune disease that predominantly affects the
joints. The prevalence of RA varies globally, with generally a higher prevalence in …

Abstract Document Reviewers: Rudolf A. de Boer (CPG Review Coordinator)(Netherlands),
P. Christian Schulze (CPG Review Coordinator)(Germany), Magdy Abdelhamid (Egypt) …

Heart Failure (HF) is a multi-faceted and life-threatening syndrome characterized by
significant morbidity and mortality, poor functional capacity and quality of life, and high costs …