Increases in calorie consumption and sedentary lifestyles are fuelling a global pandemic of
cardiometabolic diseases, including coronary artery disease, diabetes mellitus …

The global prevalence of metabolic diseases such as type 2 diabetes mellitus,
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …

Data currently generated in the field of nutrition are becoming increasingly complex and
high-dimensional, bringing with them new methods of data analysis. The characteristics of …

The human plasma lipidome captures risk for cardiometabolic diseases. To discover new
lipid-associated variants and understand the link between lipid species and cardiometabolic …

Given the limited accuracy of clinically used risk scores such as the Systematic COronary
Risk Evaluation 2 system and the Second Manifestations of ARTerial disease 2 risk scores …

Ceramides, composed of a sphingosine and a fatty acid, are bioactive lipid molecules
involved in many key cellular pathways (eg, apoptosis, oxidative stress and inflammation) …

Ceramides are bioactive lipids that have an important role in many cellular functions such as
apoptosis and inflammation. During the past decade emerging clinical data have shown that …

BACKGROUND: Gut microbiota have been implicated in atherosclerotic disease, but their
relation with subclinical coronary atherosclerosis is unclear. This study aimed to identify …

Atherosclerotic cardiovascular disease (ASCVD) proceeds through a series of stages:
initiation, progression (or regression), and complications. By integrating known biology …

Metabolic dysfunction is intertwined with the pathophysiology of both diabetes and
cardiovascular disease. Recently, one particular lipid class has been shown to influence the …