Neutrophil extracellular traps in homeostasis and disease

H Wang, SJ Kim, Y Lei, S Wang, H Wang… - … and Targeted Therapy, 2024 - nature.com
Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are
renowned for their propensity to expel decondensed chromatin embedded with inflammatory …

New therapeutic targets for the prevention and treatment of venous thromboembolism with a focus on factor XI inhibitors

NC Chan, JI Weitz - Arteriosclerosis, Thrombosis, and Vascular …, 2023 - Am Heart Assoc
FXI (factor XI) and FXII (factor XII) have emerged as targets for new anticoagulants that have
the potential to be both more efficacious and safer than the currently available direct oral …

Immobility-associated thromboprotection is conserved across mammalian species from bear to human

M Thienel, JB Müller-Reif, Z Zhang, V Ehreiser, J Huth… - Science, 2023 - science.org
Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary
embolism is a major cause of morbidity and mortality. Short-term immobility-related …

Neutrophil extracellular traps mediate deep vein thrombosis: from mechanism to therapy

M Yao, J Ma, D Wu, C Fang, Z Wang, T Guo… - Frontiers in …, 2023 - frontiersin.org
Deep venous thrombosis (DVT) is a part of venous thromboembolism (VTE) that clinically
manifests as swelling and pain in the lower limbs. The most serious clinical complication of …

Biomarkers of cell damage, neutrophil and macrophage activation associated with in-hospital mortality in geriatric COVID-19 patients

M Cardelli, E Pierpaoli, F Marchegiani, F Marcheselli… - Immunity & …, 2022 - Springer
Background The risk for symptomatic COVID-19 requiring hospitalization is higher in the
older population. The course of the disease in hospitalised older patients may show …

Neutrophil extracellular trap formation is an independent risk factor for occult cancer in patients presenting with venous thromboembolism

A Rosell, G Gautam, F Wannberg, H Ng, H Gry… - Journal of Thrombosis …, 2023 - Elsevier
Background Venous thromboembolism (VTE), particularly unprovoked VTE, is associated
with occult cancer. The optimal screening regimen remains controversial. Neutrophil …

Therapeutic Potential of DNases in Immunothrombosis: Promising Succor or Uncertain Future?

S Zalghout, K Martinod - Journal of Thrombosis and Haemostasis, 2024 - Elsevier
Sepsis, a life-threatening condition characterized by systemic inflammation and multi-organ
dysfunction, is closely associated with the excessive formation of neutrophil extracellular …

Identifying neutrophil extracellular traps (NETs) in blood samples using peripheral smear autoanalyzers

K Fedorov, M Barouqa, D Yin, M Kushnir, HH Billett… - Life, 2023 - mdpi.com
Neutrophil Extracellular Traps (NETs) are large neutrophil-derived structures composed of
decondensed chromatin, cytosolic, and granule proteins. NETs play an important role in …

Oxidative stress in acute pulmonary embolism: emerging roles and therapeutic implications

J Yang, J Xu, S Xu, Z Fan, C Zhu, J Wan, J Yang… - Thrombosis …, 2024 - Springer
Oxidative stress is an imbalance between the body's reactive oxygen species and
antioxidant defense mechanisms. Oxidative stress is involved in the development of several …

HSYA ameliorates venous thromboembolism by depleting the formation of TLR4/NF-κB pathway-dependent neutrophil extracellular traps

Y Li, J Gu, J Ge, J Kong, L Shang - International Immunopharmacology, 2024 - Elsevier
Neutrophil extracellular traps (NETs), released by activated neutrophils, are implicated in
various medical conditions, including venous thromboembolism (VTE). To develop effective …