Recent advancements in typical friedel–crafts alkylation reactions focused on targeting arene nucleophiles

S Singh, CK Hazra - Synthesis, 2024 - thieme-connect.com
This review delves into recent advances and significant breakthroughs in the field of the
catalytic Friedel–Crafts alkylation of targeted arenes or heteroarenes. Though a few earlier …

Photoredox-enabled dearomative [2π+ 2σ] cycloaddition of phenols

S Dutta, D Lee, K Ozols, CG Daniliuc… - Journal of the …, 2024 - ACS Publications
Dearomative photocycloaddition of monocyclic arenes is an appealing strategy for
comprehending the concept of “escape from flatland”. This brings the replacement of readily …

Csp 2–H functionalization of phenols: an effective access route to valuable materials via Csp 2–C bond formation

G Brufani, B Di Erasmo, CJ Li, L Vaccaro - Chemical Science, 2024 - pubs.rsc.org
In the vast majority of top-selling pharmaceutical and industrial products, phenolic structural
motifs are highly prevalent. Non-functionalized simple phenols serve as building blocks in …

Lewis Acid‐Promoted Domino Processes for the Synthesis of Homoallylic Amines, Quinolines and Tetrahydroquinolines

R Vishwakarma, N Vodnala, D Musib… - Advanced Synthesis …, 2024 - Wiley Online Library
Herein, the synthesis of homoallylic amines, quinolines, and tetrahydroquinolines has been
demonstrated. The domino one‐pot multi‐component approach has been accomplished …

Synthesis of tetralone and indanone derivatives via cascade reductive Friedel–Crafts alkylation/cyclization of keto acids/esters

N Yadav, R Mahato, J Khan, H Jaiswal… - Chemical …, 2024 - pubs.rsc.org
We disclose herein a metal-free cascade reductive Friedel–Crafts alkylation/cyclization of
keto acids/esters for the synthesis of tetralones and indanones. Owing to the simple reaction …

TsOH-catalyzed dehydroxylative cross-coupling of alcohols with phenols: rapid access to propofol derivatives

Y Liang, C Liu, Y Li, L Ouyang - RSC advances, 2024 - pubs.rsc.org
Modification of the parent structure of molecules often alters their physicochemical
properties and biological activities. Herein, a practical, efficient, and highly regioselective C …

Cu(II) Promoted C(sp3)−H Activation in Unactivated Cycloalkanes: Oxo‐Alkylation of Styrenes to Synthesize β‐Disubstituted Ketones

KM Das, A Pal, L Surya T, L Roy… - Chemistry–A European …, 2024 - Wiley Online Library
We report the Cu (II) catalyzed synthesis of β‐disubstituted ketones from styrene via oxo‐
alkylation with unactivated cycloalkanes as the alkylating agent in presence of tert …

Catalyst-Switchable Divergent Synthesis of Bis (indolyl) alkanes and 3-Alkylated Indoles from Styrene Oxides

A Tyagi, J Khan, N Yadav, R Mahato… - The Journal of Organic …, 2022 - ACS Publications
A novel and effective Brønsted acid-catalyzed chemoselective synthesis of bis (indolyl)
alkanes and 3-alkyl indoles is reported. The selectivity of two significant indole derivatives is …

Nondirected Ortho C–H Arylation for One-Pot Synthesis of Biaryl Scaffolds via In Situ Generated Mixed Acetal

A Tyagi, H Gautam, K Tripathi… - The Journal of Organic …, 2024 - ACS Publications
Herein, we introduce a mild and efficient method for synthesizing aniline biaryls and
unsymmetrical phenol biaryls through iodine-catalyzed coupling of quinone imine ketals …

Cobalt (II)-Catalyzed Synthesis of γ-Diketones from Aryl Alkenes and Its Utilization in the Synthesis of Various Heterocyclic Compounds

S Sau, KM Das, B Mondal, A Thakur - The Journal of Organic …, 2024 - ACS Publications
An earth-abundant Co (II) salt-catalyzed mild and affordable synthetic route has been
developed for the synthesis of industrially relevant 1, 4-dicarbonyl compounds (or γ …