Stem cell systems regulate tissue development and maintenance. The germline stem cell
system is essential for animal reproduction, controlling both the timing and number of …

Sexual reproduction requires the production of haploid gametes (sperm and egg) with only
one copy of each chromosome; fertilization then restores the diploid chromosome content in …

The C. elegans germline provides an excellent model for analyzing the regulation of stem
cell activity and the decision to differentiate and undergo meiotic development. The distal …

Stem cells are essential for tissue generation during the development of multicellular
creatures, and for tissue homeostasis in adults. The great therapeutic promise of stem cells …

During meiosis, telomere attachment to the inner nuclear envelope is required for proper
pairing of homologous chromosomes and recombination. Here, we identified F-box protein …

During meiosis, the maternal and paternal homologous chromosomes must align along their
entire length and recombine to achieve faithful segregation in the gametes. Meiotic …

Modified nucleoside triphosphates (NTPs) are powerful probes and medicines, but their
anionic character impedes membrane permeability. As such, invasive delivery techniques …

Telomere bouquet formation, a highly conserved meiotic event, plays an important role in
homologous pairing and therefore progression of meiosis; however, the underlying …

Germ cells have the ability to differentiate into eggs and sperm and must determine their
sexual fate. In vertebrates, the mechanism of commitment to oogenesis following the sexual …

The Caenorhabditis elegans inner nuclear envelope protein matefin/SUN-1 plays a
conserved, pivotal role in the process of genome haploidization. CHK-2–dependent …