Molecular mechanisms of melatonin-mediated cell protection and signaling in health and disease
DM Kopustinskiene, J Bernatoniene - Pharmaceutics, 2021 - mdpi.com
Melatonin, an endogenously synthesized indolamine, is a powerful antioxidant exerting
beneficial action in many pathological conditions. Melatonin protects from oxidative stress in …
beneficial action in many pathological conditions. Melatonin protects from oxidative stress in …
A cellular and molecular biology-based update for ivermectin against COVID-19: is it effective or non-effective?
M Nabi-Afjadi, F Mohebi, H Zalpoor, F Aziziyan… - …, 2023 - Springer
Despite community vaccination against coronavirus disease 2019 (COVID-19) and reduced
mortality, there are still challenges in treatment options for the disease. Due to the …
mortality, there are still challenges in treatment options for the disease. Due to the …
Sequential doxycycline and colchicine combination therapy in Covid-19: the salutary effects
Abstract Coronavirus virus disease 2019 (COVID-19) is a viral infectious disease caused by
the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), actually considered as …
the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), actually considered as …
[HTML][HTML] Integrating heterogeneous data to facilitate COVID-19 drug repurposing
LP Santamaría, MD Uzquiano, EU Carro… - Drug Discovery …, 2022 - Elsevier
In the COVID-19 pandemic, drug repositioning has presented itself as an alternative to the
time-consuming process of generating new drugs. This review describes a drug repurposing …
time-consuming process of generating new drugs. This review describes a drug repurposing …
Identification and investigation of a cryptic binding pocket of the P37 envelope protein of monkeypox virus by molecular dynamics simulations
The spread of the monkeypox virus has surged during the unchecked COVID-19 epidemic.
The most crucial target is the viral envelope protein, p37. However, lacking p37's crystal …
The most crucial target is the viral envelope protein, p37. However, lacking p37's crystal …
Unmasking an allosteric binding site of the papain-like protease in SARS-CoV-2: molecular dynamics simulations of corticosteroids
To date, mechanistic insights into many clinical drugs against COVID-19 remain unexplored.
Dexamethasone, a corticosteroid, is one of them. While treating the entire corticosteroid …
Dexamethasone, a corticosteroid, is one of them. While treating the entire corticosteroid …
Comparative efficacy and safety of pharmacological interventions for severe COVID-19 patients: An updated network meta-analysis of 48 randomized controlled trials
Q Cheng, G Zhao, J Chen, Q Jia, Z Fang - Medicine, 2022 - journals.lww.com
Background: To date, there has been little agreement on what drug is the" best" drug for
treating severe COVID-19 patients. This study aimed to assess the efficacy and safety of …
treating severe COVID-19 patients. This study aimed to assess the efficacy and safety of …
[HTML][HTML] Machine learning enabled identification of potential SARS-CoV-2 3CLpro inhibitors based on fixed molecular fingerprints and Graph-CNN neural …
J Haneczok, M Delijewski - Journal of Biomedical Informatics, 2021 - Elsevier
Aim Rapidly developing AI and machine learning (ML) technologies can expedite
therapeutic development and in the time of current pandemic their merits are particularly in …
therapeutic development and in the time of current pandemic their merits are particularly in …
Removal of doxycycline hydrochloride from aqueous solution by rice husk ash using response surface methodology and disposability study
G Kaur, N Singh, A Rajor, RK Arya - Environmental Science and Pollution …, 2023 - Springer
The huge demand and consumption of DOX, its incomplete metabolism, and complex
behavior in atmosphere are causing a great ecological issue, which needs to be solved. In …
behavior in atmosphere are causing a great ecological issue, which needs to be solved. In …
[PDF][PDF] Efficient degradation of doxycycline and ofloxacin in an aqueous environment using Fe and Cu doped TiO2-SiO2 photocatalyst under sunlight
Several drugs have sparked interest as potential COVID-19 treatment options. Doxycycline
(DOX) has been widely used with other potential agents to reduce COVID-19-induced …
(DOX) has been widely used with other potential agents to reduce COVID-19-induced …