Copper and nitrogen-doped carbon quantum dots as green nano-probes for fluorimetric determination of delafloxacin; characterization and applications

BI Salman, AI Hassan, A Al-Harrasi, AE Ibrahim… - Analytica Chimica …, 2024 - Elsevier
Abstract Background Carbon quantum dots (CQDs) have gained much interest recently for
being efficient probes. Their cost-effectiveness, eco-friendliness, and unique photocatalytic …

Improved antimicrobial activity and oral bioavailability of delafloxacin by self-nanoemulsifying drug delivery system (SNEDDS)

MK Anwer, M Iqbal, MF Aldawsari, A Alalaiwe… - Journal of Drug Delivery …, 2021 - Elsevier
In the current study, a novel self-nanoemulsifying drug delivery system (SNEDDS) was
developed in order to improve the oral bioavailability of delafloxacin (DLF). Various oils …

New Antimicrobials for Gram-Positive Sustained Infections: A Comprehensive Guide for Clinicians

D Carcione, J Intra, L Andriani, F Campanile, F Gona… - Pharmaceuticals, 2023 - mdpi.com
Antibiotic resistance is a public health problem with increasingly alarming data being
reported. Gram-positive bacteria are among the protagonists of severe nosocomial and …

Simple and accurate HPTLC-densitometric method for quantification of delafloxacin (a novel fluoroquinolone antibiotic) in plasma samples: Application to …

P Alam, M Iqbal, E Ezzeldin, NY Khalil, AI Foudah… - Antibiotics, 2020 - mdpi.com
Delafloxacin (DLX) is a recently-approved fluoroquinolone antibiotic, which is recommended
for the treatment of “acute bacterial skin and skin structure infections”. A thorough literature …

Development of Lipomer Nanoparticles for the Enhancement of Drug Release, Anti-Microbial Activity and Bioavailability of Delafloxacin

MK Anwer, M Iqbal, MM Muharram, M Mohammad… - Pharmaceutics, 2020 - mdpi.com
Delafloxacin (DFL) is a novel potent and broad-spectrum fluoroquinolone group of
antibiotics effective against both Gram-positive and negative aerobic and anaerobic …

Improving the Solubilization and Bioavailability of Arbidol Hydrochloride by the Preparation of binary and ternary β-cyclodextrin complexes with poloxamer 188

MK Anwer, M Iqbal, MM Ahmed, MF Aldawsari… - Pharmaceuticals, 2021 - mdpi.com
In the current study, the effect of poloxamer 188 on the complexation efficiency and
dissolution of arbidol hydrochloride (ADL), a broad-spectrum antiviral agent, with β …

Determination of delafloxacin in pharmaceutical formulations using a green RP-HPTLC and NP-HPTLC methods: a comparative study

P Alam, E Ezzeldin, M Iqbal, GAE Mostafa, MK Anwer… - Antibiotics, 2020 - mdpi.com
In this work; delafloxacin (DLFX) was determined using a validated green RP-HPTLC and
NP-HPTLC methods in commercial tablets and in-house developed solid lipid nanoparticles …

Mini-tablets versus nanoparticles for controlling the release of amoxicillin: In vitro/in vivo study

DA Gaber, HS Alhawas, FA Alfadhel… - Drug design …, 2020 - Taylor & Francis
Introduction Controlling the drug release from the dosage form at a definite rate is the main
challenge for a successful oral controlled-release drug delivery system. In this study, mini …

Multi-walled carbon nanotubes/polyaniline covalently attached 18-crown-6-ether as a polymeric material for the potentiometric determination of delafloxacin

NA Abdallah, YM Alahmadi, R Bafail… - Journal of Applied …, 2022 - Springer
In recent years, the global emergence of antibacterial resistance has led to the development
of new antibacterial drugs with unique chemical structures. The FDA has recently approved …

Eco-friendly uplc-ms/ms quantitation of delafloxacin in plasma and its application in a pharmacokinetic study in rats

M Iqbal, E Ezzeldin, MK Anwer, F Imam - Separations, 2021 - mdpi.com
A novel UPLC-MS/MS assay was developed for rapid quantification of delafloxacin (a novel
fluoroquinolone antibiotic in plasma samples by one step sample cleanup procedure …