Lost in condensation: poly-, cyclo-, and ultraphosphates
Conspectus Much like linear, branched, and cyclic alkanes, condensed phosphates exist as
linear, branched, and cyclic structures. Inasmuch as alkanes are the cornerstone of organic …
linear, branched, and cyclic structures. Inasmuch as alkanes are the cornerstone of organic …
Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains
Phosphorus is a macronutrient taken up by cells as inorganic phosphate (Pi). How cells
sense cellular Pi levels is poorly characterized. Here, we report that SPX domains—which …
sense cellular Pi levels is poorly characterized. Here, we report that SPX domains—which …
Prodrugs of pyrophosphates and bisphosphonates: disguising phosphorus oxyanions
ES Rudge, AHY Chan, FJ Leeper - RSC Medicinal Chemistry, 2022 - pubs.rsc.org
Pyrophosphates have important functions in living systems and thus pyrophosphate-
containing molecules and their more stable bisphosphonate analogues have the potential to …
containing molecules and their more stable bisphosphonate analogues have the potential to …
Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues
Technical challenges have to date prevented a complete profiling of the levels of myo-
inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) in mammalian tissues. Here, we …
inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) in mammalian tissues. Here, we …
Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo
I Pavlovic, DT Thakor, JR Vargas, CJ McKinlay… - Nature …, 2016 - nature.com
Inositol pyrophosphates, such as diphospho-myo-inositol pentakisphosphates (InsP7), are
an important family of signalling molecules, implicated in many cellular processes and …
an important family of signalling molecules, implicated in many cellular processes and …
[HTML][HTML] Itraconazole inhibits endothelial cell migration by disrupting inositol pyrophosphate-dependent focal adhesion dynamics and cytoskeletal remodeling
J Qi, W Cheng, Z Gao, Y Chen, ML Shipton… - Biomedicine & …, 2023 - Elsevier
The antifungal drug itraconazole has been repurposed to anti-angiogenic agent, but the
mechanisms of action have been elusive. Here we report that itraconazole disrupts focal …
mechanisms of action have been elusive. Here we report that itraconazole disrupts focal …
6-Thioguanosine monophosphate prodrugs display enhanced performance against thiopurine-resistant leukemia and breast cancer cells
Thiopurines are in widespread clinical use for the treatment of immunological disorders and
certain cancers. However, treatment failure due to resistance or adverse drug reactions are …
certain cancers. However, treatment failure due to resistance or adverse drug reactions are …
A 1-phytase type III effector interferes with plant hormone signaling
Most Gram-negative phytopathogenic bacteria inject type III effector (T3E) proteins into plant
cells to manipulate signaling pathways to the pathogen's benefit. In resistant plants …
cells to manipulate signaling pathways to the pathogen's benefit. In resistant plants …
Scalable chemoenzymatic synthesis of inositol pyrophosphates
R Puschmann, RK Harmel, D Fiedler - Biochemistry, 2019 - ACS Publications
The inositol pyrophosphates (PP-InsPs) are an important group of cellular messengers that
influence a broad range of biological processes. To elucidate the functions of these high …
influence a broad range of biological processes. To elucidate the functions of these high …
The p K a of Brønsted acids controls their reactivity with diazo compounds
N Fei, B Sauter, D Gillingham - Chemical Communications, 2016 - pubs.rsc.org
We study the O-alkylation of phosphate groups by alkyl diazo compounds in a range of small
molecules and biopolymers. We show that the relatively high pKa of phosphate in …
molecules and biopolymers. We show that the relatively high pKa of phosphate in …