Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Investigations in the last 10 years have revealed a new category of neurological diseases
mediated by antibodies against cell surface and synaptic proteins. There are currently 16 …

Objective: This nationwide study gives a detailed description of the clinical features and long-
term outcome of anti–leucine-rich glioma-inactivated 1 (LGI1) encephalitis. Methods: We …

NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-
permeable component of excitatory neurotransmission in the central nervous system (CNS) …

NMDA receptors (NMDARs) are glutamate-gated ion channels and are crucial for neuronal
communication. NMDARs form tetrameric complexes that consist of several homologous …

Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests …

The molecular components of the postsynaptic density (PSD) in excitatory synapses of the
brain are currently being investigated as one of the major etiologies of neurodevelopmental …

Clinical studies show that chronic pain is accompanied by memory deficits and reduction in
hippocampal volume. Experimental studies show that spared nerve injury (SNI) of the sciatic …

Anti-N-methyl D-aspartate receptor (NMDAR) encephalitis is a severe neuropsychiatric
disorder that associates with prominent memory and behavioural deficits. Patients' …

l-lactate is a product of aerobic glycolysis that can be used by neurons as an energy
substrate. Here we report that in neurons l-lactate stimulates the expression of synaptic …