Over the past decade, cross-linking mass spectrometry (CLMS) has developed into a robust
and flexible tool that provides medium-resolution structural information. CLMS data provide …

In recent years, chemical crosslinking of protein complexes and the identification of
crosslinked residues by mass spectrometry (XL-MS; sometimes abbreviated as CX-MS) has …

Scarcity of structural and evolutionary information on protein complexes poses a challenge
to deep learning-based structure modelling. We integrate experimental distance restraints …

After more than a decade of method development, cross-linking in combination with mass
spectrometry and bioinformatics is finally coming of age. This technology now provides …

Chemical cross-linking of reactive groups in native proteins and protein complexes in
combination with the identification of cross-linked sites by mass spectrometry has been in …

The evolution of mass spectrometry–based proteomic technologies has advanced our
understanding of the complex and dynamic nature of proteomes while concurrently …

Crosslinking mass spectrometry (crosslinking-MS) is a versatile tool providing structural
insights into protein conformation and protein-protein interactions. Its medium-resolution …

Knowledge of elaborate structures of protein complexes is fundamental for understanding
their functions and regulations. Although cross-linking coupled with mass spectrometry (MS) …

Kinetochores are proteinaceous assemblies that mediate the interaction of chromosomes
with the mitotic spindle. The 180 kDa Ndc80 complex is a direct point of contact between …

Kinetochores are large protein assemblies built on chromosomal loci named centromeres.
The main functions of kinetochores can be grouped under four modules. The first module, in …