Tumor necrosis factor (TNF) is the prototypic pro-inflammatory cytokine. It is central to host
defense and inflammatory responses but under certain circumstances also triggers cell …

Sepsis and septic shock are among the leading causes of death in intensive care units
worldwide. Numerous studies on their pathophysiology have revealed an imbalance in the …

Tumor necrosis factor-α (TNFα) was cloned over 2 decades ago and its identification in part
led to the discovery of a super family of tumor necrosis factors (TNFs) and their receptors …

Tumor necrosis factor-α (TNF-α) has been shown to have certain catabolic effects on fat cells
and whole animals. An induction of TNF-α messenger RNA expression was observed in …

Many diverse activities of tumor necrosis factor (TNF) are signaled through TNF receptor 1
(TNFRl). We have identified a novel 34 kDa protein, designated TRADD, that specifically …

Abstract Turnbull, Andrew V., and Catherine L. Rivier. Regulation of the Hypothalamic-
Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action. Physiol. Rev. 79: 1 …

Studies on mice deficient in nuclear factor kappa B (NF-κB) subunits have shown that this
transcription factor is important for lymphocyte responses to antigens and cytokine-inducible …

Osteoclast differentiation factor (ODF, also called RANKL/TRANCE/OPGL) stimulates the
differentiation of osteoclast progenitors of the monocyte/macrophage lineage into …

Tumor necrosis factor (TNF) can induce apoptosis and activate NF-κB through signaling
cascades emanating from TNF receptor 1 (TNFR1). TRADD is a TNFR1-associated signal …

Morphological changes observed in OA include cartilage erosion as well as a variable
degree of synovial inflammation. Current research attributes these changes to a complex …