The structure of the nuclear pore complex (an update)
The nuclear pore complex (NPC) serves as the sole bidirectional gateway of
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …
Nuclear pore complexes—a doorway to neural injury in neurodegeneration
AN Coyne, JD Rothstein - Nature Reviews Neurology, 2022 - nature.com
The genetic underpinnings and end-stage pathological hallmarks of neurodegenerative
diseases are increasingly well defined, but the cellular pathophysiology of disease initiation …
diseases are increasingly well defined, but the cellular pathophysiology of disease initiation …
[HTML][HTML] Comprehensive structure and functional adaptations of the yeast nuclear pore complex
CW Akey, D Singh, C Ouch, I Echeverria, I Nudelman… - Cell, 2022 - cell.com
Nuclear pore complexes (NPCs) mediate the nucleocytoplasmic transport of
macromolecules. Here we provide a structure of the isolated yeast NPC in which the inner …
macromolecules. Here we provide a structure of the isolated yeast NPC in which the inner …
Nuclear pores as versatile reference standards for quantitative superresolution microscopy
Quantitative fluorescence and superresolution microscopy are often limited by insufficient
data quality or artifacts. In this context, it is essential to have biologically relevant control …
data quality or artifacts. In this context, it is essential to have biologically relevant control …
Architecture of the linker-scaffold in the nuclear pore
INTRODUCTION In eukaryotic cells, the selective bidirectional transport of macromolecules
between the nucleus and cytoplasm occurs through the nuclear pore complex (NPC) …
between the nucleus and cytoplasm occurs through the nuclear pore complex (NPC) …
Structure and assembly of the nuclear pore complex
B Hampoelz, A Andres-Pons… - Annual review of …, 2019 - annualreviews.org
Nuclear pore complexes (NPCs) mediate nucleocytoplasmic exchange. They are
exceptionally large protein complexes that fuse the inner and outer nuclear membranes to …
exceptionally large protein complexes that fuse the inner and outer nuclear membranes to …
In-cell architecture of the nuclear pore and snapshots of its turnover
Nuclear pore complexes (NPCs) fuse the inner and outer membranes of the nuclear
envelope. They comprise hundreds of nucleoporins (Nups) that assemble into multiple …
envelope. They comprise hundreds of nucleoporins (Nups) that assemble into multiple …
Docking a flexible basket onto the core of the nuclear pore complex
E Stankunas, A Köhler - Nature Cell Biology, 2024 - nature.com
The nuclear basket attaches to the nucleoplasmic side of the nuclear pore complex (NPC),
coupling transcription to mRNA quality control and export. The basket expands the …
coupling transcription to mRNA quality control and export. The basket expands the …
G4C2 repeat RNA initiates a POM121-mediated reduction in specific nucleoporins in C9orf72 ALS/FTD
Through mechanisms that remain poorly defined, defects in nucleocytoplasmic transport and
accumulations of specific nuclear-pore-complex-associated proteins have been reported in …
accumulations of specific nuclear-pore-complex-associated proteins have been reported in …
Nuclear pore complexes mediate subtelomeric gene silencing by regulating PCNA levels on chromatin
The nuclear pore complex (NPC) physically interacts with chromatin and regulates gene
expression. The Saccharomyces cerevisiae inner ring nucleoporin Nup170 has been …
expression. The Saccharomyces cerevisiae inner ring nucleoporin Nup170 has been …