Microbial pigments as natural color sources: current trends and future perspectives

HS Tuli, P Chaudhary, V Beniwal… - Journal of food science and …, 2015 - Springer
Synthetic colors have been widely used in various industries including food, textile, cosmetic
and pharmaceuticals. However toxicity problems caused by synthetic pigments have …

Chalcone scaffolds as anti-infective agents: Structural and molecular target perspectives

DK Mahapatra, SK Bharti, V Asati - European journal of medicinal chemistry, 2015 - Elsevier
In recent years, widespread outbreak of numerous infectious diseases across the globe has
created havoc among the population. Particularly, the inhabitants of tropical and sub-tropical …

Color me bad: microbial pigments as virulence factors

GY Liu, V Nizet - Trends in microbiology, 2009 - cell.com
A hallmark feature of several pathogenic microbes is the distinctive color of their colonies
when propagated in the clinical laboratory. Such pigmentation comes in a variety of hues …

Advances in the research on the targets of anti-malaria actions of artemisinin

J Yang, Y He, Y Li, X Zhang, YK Wong, S Shen… - Pharmacology & …, 2020 - Elsevier
Malaria has been a global epidemic health threat since ancient times. It still claims roughly
half a million lives every year in this century. Artemisinin and its derivatives, are frontline …

Antimalarial quinoline drugs inhibit β-hematin and increase free hemin catalyzing peroxidative reactions and inhibition of cysteine proteases

T Herraiz, H Guillén, D González-Peña, VJ Arán - Scientific reports, 2019 - nature.com
Malaria caused by Plasmodium affects millions people worldwide. Plasmodium consumes
hemoglobin during its intraerythrocytic stage leaving toxic heme. Parasite detoxifies free …

Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds

EM Guantai, K Ncokazi, TJ Egan, J Gut… - Bioorganic & medicinal …, 2010 - Elsevier
A targeted series of chalcone and dienone hybrid compounds containing aminoquinoline
and nucleoside templates was synthesized and evaluated for in vitro antimalarial activity …

Pharmacologic treatment of transplant recipients infected with SARS-CoV-2: considerations regarding therapeutic drug monitoring and drug–drug interactions

L Elens, LJ Langman, DA Hesselink… - Therapeutic drug …, 2020 - journals.lww.com
Background: COVID-19 is a novel infectious disease caused by the severe acute respiratory
distress (SARS)-coronavirus-2 (SARS-CoV-2). Several therapeutic options are currently …

Recent advances in understanding the mechanism of hemozoin (malaria pigment) formation

TJ Egan - Journal of inorganic biochemistry, 2008 - Elsevier
The recent literature on hemozoin/β-hematin formation is reviewed, with an emphasis on the
mechanism of its formation. Recent findings from unrelated organisms that produce …

Metalloantimalarials

PF Salas, C Herrmann, C Orvig - Chemical reviews, 2013 - ACS Publications
Malaria is a worldwide neglected infectious disease that, despite decades of research
invested in its prevention and treatment, remains one of the main causes of mortality and …

Discovery of dual function acridones as a new antimalarial chemotype

JX Kelly, MJ Smilkstein, R Brun, S Wittlin, RA Cooper… - Nature, 2009 - nature.com
Preventing and delaying the emergence of drug resistance is an essential goal of
antimalarial drug development. Monotherapy and highly mutable drug targets have each …