DK Mahapatra, SK Bharti, V Asati - European journal of medicinal chemistry, 2015 - Elsevier
In recent years, widespread outbreak of numerous infectious diseases across the globe has created havoc among the population. Particularly, the inhabitants of tropical and sub-tropical …
GY Liu, V Nizet - Trends in microbiology, 2009 - cell.com
A hallmark feature of several pathogenic microbes is the distinctive color of their colonies when propagated in the clinical laboratory. Such pigmentation comes in a variety of hues …
J Yang, Y He, Y Li, X Zhang, YK Wong, S Shen… - Pharmacology & …, 2020 - Elsevier
Malaria has been a global epidemic health threat since ancient times. It still claims roughly half a million lives every year in this century. Artemisinin and its derivatives, are frontline …
Malaria caused by Plasmodium affects millions people worldwide. Plasmodium consumes hemoglobin during its intraerythrocytic stage leaving toxic heme. Parasite detoxifies free …
EM Guantai, K Ncokazi, TJ Egan, J Gut… - Bioorganic & medicinal …, 2010 - Elsevier
A targeted series of chalcone and dienone hybrid compounds containing aminoquinoline and nucleoside templates was synthesized and evaluated for in vitro antimalarial activity …
L Elens, LJ Langman, DA Hesselink… - Therapeutic drug …, 2020 - journals.lww.com
Background: COVID-19 is a novel infectious disease caused by the severe acute respiratory distress (SARS)-coronavirus-2 (SARS-CoV-2). Several therapeutic options are currently …
TJ Egan - Journal of inorganic biochemistry, 2008 - Elsevier
The recent literature on hemozoin/β-hematin formation is reviewed, with an emphasis on the mechanism of its formation. Recent findings from unrelated organisms that produce …
PF Salas, C Herrmann, C Orvig - Chemical reviews, 2013 - ACS Publications
Malaria is a worldwide neglected infectious disease that, despite decades of research invested in its prevention and treatment, remains one of the main causes of mortality and …
JX Kelly, MJ Smilkstein, R Brun, S Wittlin, RA Cooper… - Nature, 2009 - nature.com
Preventing and delaying the emergence of drug resistance is an essential goal of antimalarial drug development. Monotherapy and highly mutable drug targets have each …