New evidence has challenged the outdated dogma that neutrophils are a homogeneous
population of short-lived cells. Although neutrophil subpopulations with distinct functions …

Studies have reported a positive correlation between elevated CD8+ T cells in the tumor
microenvironment (TME) and good prognosis in cancer. However, the mechanisms linking T …

Liver cancer has the fourth highest mortality rate of all cancers worldwide, with
hepatocellular carcinoma (HCC) being the most prevalent subtype. Despite great advances …

In cancer, infection and inflammation, the immune system's function can be dysregulated.
Instead of fighting disease, immune cells may increase pathology and suppress host …

Purpose: Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of
pathologically expanded myeloid cells with immunosuppressive activity. In human disease …

Immune-checkpoint blockade (ICB) demonstrated inspiring effect and great promise in anti-
cancer therapy. However, many obstacles, such as drug resistance and difficulty in patient …

The immunopathology of coronavirus disease 2019 (COVID-19) remains enigmatic, causing
immunodysregulation and T cell lymphopenia. Monocytic myeloid-derived suppressor cells …

Cancer immunotherapy is a type of treatment that harnesses the power of the immune
systems of patients to target cancer cells with better precision compared to traditional …

Pancreatic cancer is one of the most malignant tumors with increased incidence rate. The
effect of surgery combined with chemoradiotherapy on survival of patients is unsatisfactory …

Neutrophils are the most abundant leukocytes in human peripheral blood, comprising about
70% of all leukocytes. They are regarded as the first line of defense of the innate immune …