EpCAM (epithelial cell adhesion molecule) was discovered four decades ago as a tumor
antigen on colorectal carcinomas. Owing to its frequent and high expression on carcinomas …

Human pluripotent embryonic stem cells have two special features: self-renewal and
pluripotency. It is important to understand the properties of pluripotent stem cells and …

Cell type-specific gene expression patterns are outputs of transcriptional gene regulatory
networks (GRNs) that connect transcription factors and signaling proteins to target genes …

Partial pluripotent reprogramming can reverse features of aging in mammalian cells, but the
impact on somatic identity and the necessity of individual reprogramming factors remain …

Embryonic stem cells (ESCs) have transcriptionally permissive chromatin enriched for gene
activation–associated histone modifications. A striking exception is DOT1L-mediated H3K79 …

Reprogramming human fibroblasts to induced pluripotent stem cells (iPSCs) is inefficient,
with heterogeneity among transcription factor (TF) trajectories driving divergent cell states …

Transcription factor (TF)-induced reprogramming of somatic cells across lineages and to
induced pluripotent stem cells (iPSCs) has revealed a remarkable plasticity of differentiated …

Yamanaka factors (YFs) can reverse some aging features in mammalian tissues, but their
effects on the brain remain largely unexplored. Here, we induced YFs in the mouse brain in …

Heat shock protein family A member 8 (HSPA8) participates in the folding or degradation of
misfolded proteins under stress and plays critical roles in cancer. In this study, we …

Background Precise gene dosage of the X chromosomes is critical for normal development
and cellular function. In mice, XX female somatic cells show transcriptional X chromosome …