Protein–protein interactions (PPI) were once considered 'undruggable', but clinical
successes, driven by advanced methods in drug discovery, have challenged that notion …

The 6 high-affinity insulin-like growth factor binding proteins (IGFBPs) are multifunctional
proteins that modulate cell signaling through multiple pathways. Their canonical function at …

Insulin-like growth factor binding protein-3 (IGFBP-3) is a p53 tumor suppressor-regulated
protein and a major carrier for IGFs in circulation. Among six high-affinity IGFBPs, which are …

It is well-recognized that cigarette smoking is a primary risk factor in the development of non-
small cell lung cancer (NSCLC), known to account for~ 80% of all lung cancers with nicotine …

Simple Summary Humanin is a small mitochondrial-derived peptide still under study, with a
number of potential therapeutic applications for various age-related diseases. It plays an …

Humanin (HN) belongs to a member of mitochondrial-derived peptides (MDPs) which are
encoded by mitochondrial genes. HN shares sequence homology with thirteen HN-like …

Background and Purpose—Ischemic stroke, a complex and heterogeneous disease, is the
second leading cause of death worldwide. Genetic factors and epigenetic modification …

The ectodomain of the transmembrane protein E-cadherin can be cleaved and released in a
soluble form referred to as soluble E-cadherin, or sE-cad, accounting for decreased E …

Cisplatin is a platinum agent used in the treatment of non-small cell lung cancer (NSCLC).
Much remains unknown regarding the basic operative mechanisms underlying cisplatin …

Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the
etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive …