The extensive usage of antibiotics and the rapid emergence of antimicrobial-resistant
microbes (AMR) are becoming important global public health issues. Many solutions to …

Tuberculosis still remains one of the most common, communicable, and leading deadliest
diseases known to mankind throughout the world. Drug-resistance in Mycobacterium …

Several phenyl substituted naphthalenes and isoquinolines have been identified as
antibacterial agents that inhibit FtsZ-Zing formation. In the present study we evaluated the …

Similar to its eukaryotic counterpart, the prokaryotic cytoskeleton is essential for the
structural and mechanical properties of bacterial cells. The essential protein FtsZ is a central …

Emerging antibiotic resistance in bacteria endorses the failure of existing drugs with chronic
illness, complicated treatment, and ever-increasing expenditures. Bacteria acquire the …

The clinical development of FtsZ-targeting benzamide compounds like PC190723 has been
limited by poor drug-like and pharmacokinetic properties. Development of prodrugs of …

The cooperative assembly of FtsZ, the prokaryotic homologue of tubulin, plays an essential
role in cell division. FtsZ is a potential drug target, as illustrated by the small-molecule cell …

FtsZ is the key protein of bacterial cell division and an emergent target for new antibiotics. It
is a filament-forming GTPase and a structural homologue of eukaryotic tubulin. A number of …

The first Ru-catalyzed redox-neutral C–H activation reaction via N–N bond cleavage is
reported. Pyrazolidin-3-one is demonstrated as an internally oxidative directing group that …

The bacterial cell division protein FtsZ is an attractive target for small-molecule antibacterial
drug discovery. Derivatives of 3-methoxybenzamide, including compound PC190723, have …