This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

Abstract P2Y receptors are G protein‐coupled receptors (GPCRs) that are activated by
adenine and uridine nucleotides and nucleotide sugars. There are eight subtypes of P2Y …

ABSTRACT Transmembrane member 16A (TMEM16A) is the Ca2+‐activated chloride
channel in airways and intestine. It has been associated with goblet cell metaplasia, as …

To cite this article: Müller T, Robaye B, Vieira RP, Ferrari D, Grimm M, Jakob T, Martin SF, Di
Virgilio F, Boeynaems J‐M, Virchow JC, Idzko M. The purinergic receptor P2Y2 receptor …

Extracellular nucleotides (eg, ATP) regulate many physiological and pathophysiological pro‐
cesses through activation of nucleotide (P2) receptors in the plasma membrane. Here we …

Purinergic signalling plays major roles in the physiology and pathophysiology of digestive
organs. Adenosine 5′-triphosphate (ATP), together with nitric oxide and vasoactive …

Extracellular ATP acts as a “danger signal” and can induce inflammation by binding to
purinergic receptors. Chronic obstructive pulmonary disease is one of the most common …

Epithelial cells of the gastrointestinal tract are an important barrier between the “milieu
interne” and the luminal content of the gut. They perform transport of nutrients, salts, and …

Growing evidence implicates a key role for extracellular nucleotides in cellular regulation,
including of ion channels and renal function, but the mechanisms for such actions are …

Renal tubular epithelial cells receive hormonal input that regulates volume and electrolyte
homeostasis. In addition, numerous intrarenal, local signaling agonists have appeared on …