Tuberculosis remains a global health problem, with an estimated 10.4 million cases and 1.8
million deaths resulting from the disease in 2015. The most lethal and disabling form of …

Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the
brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM) …

Humans are exposed to a variety of environmental mycobacteria (EM), and most children
are inoculated with live Bacille Calmette-Guérin (BCG) vaccine. In addition, most of the …

Background Susceptibility to disease after infection by Mycobacterium tuberculosis is
influenced by environmental and host genetic factors. Vitamin D metabolism leads to …

The complement system comprises several fluid-phase and membrane-associated proteins.
Under physiological conditions, activation of the fluid-phase components of complement is …

The factors that govern the development of tuberculosis disease are incompletely
understood. We hypothesized that some strains of Mycobacterium tuberculosis (M …

When the adaptive immune response is either immature or compromised, the innate
immune system constitutes the principle defense against infection. Mannose-binding lectin …

The evidence for a human genetic component in susceptibility to tuberculosis (TB) is
incontrovertible. Quite apart from studies of rare disease events illustrating the importance of …

Mannan-binding lectin (MBL) is a plasma protein found in association with several serine
proteases (MASPs) forming the MBL complex. MBL recognises carbohydrate structures …

Mannan-binding lectin (MBL) is a collectin (protein with both collagen-like and C-type lectin
domains) synthesised in the liver and secreted into the bloodstream. Its plasma …