GeneCompass: deciphering universal gene regulatory mechanisms with a knowledge-informed cross-species foundation model

X Yang, G Liu, G Feng, D Bu, P Wang, J Jiang, S Chen… - Cell Research, 2024 - nature.com
Deciphering universal gene regulatory mechanisms in diverse organisms holds great
potential for advancing our knowledge of fundamental life processes and facilitating clinical …

Multiomic analysis of cohesin reveals that ZBTB transcription factors contribute to chromatin interactions

R Wang, Q Xu, C Wang, K Tian, H Wang… - Nucleic Acids …, 2023 - academic.oup.com
One bottleneck in understanding the principles of 3D chromatin structures is caused by the
paucity of known regulators. Cohesin is essential for 3D chromatin organization, and its …

Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation

I Tiniakou, PF Hsu, LS Lopez-Zepeda, G Garipler… - Science …, 2024 - science.org
The development of dendritic cells (DCs), including antigen-presenting conventional DCs
(cDCs) and cytokine-producing plasmacytoid DCs (pDCs), is controlled by the growth factor …

Dimerization choice and alternative functions of ZBTB transcription factors

S Barakat, E Ezen, İ Devecioğlu, M Gezen… - The FEBS …, 2024 - Wiley Online Library
Zinc Finger DNA‐binding domain‐containing proteins are the most populous family among
eukaryotic transcription factors. Among these, members of the BTB domain‐containing ZBTB …

Knockdown of ZBTB11 impedes R‐loop elimination and increases the sensitivity to cisplatin by inhibiting DDX1 transcription in bladder cancer

L Chen, Z Liu, H Tang, Z Zhou, J Chen, Z Ma… - Cell …, 2022 - Wiley Online Library
Introduction Bladder cancer (BC) is one of the most common malignant cancers, with poor
prognosis and high incidence. Cisplatin is the standard chemotherapy for muscle invasive …

TRIM28 regulates transcriptional activity of methyl-DNA binding protein Kaiso by SUMOylation

Y Lobanova, G Filonova, D Kaplun, N Zhigalova… - Biochimie, 2023 - Elsevier
Kaiso is a methyl DNA binding transcriptional factor involved in cell cycle control, WNT
signaling, colon inflammation, and cancer progression. Recently, it was shown that …

Late fetal hematopoietic failure results from ZBTB11 deficiency despite abundant HSC specification

H Cao, SH Naik, D Amann-Zalcenstein… - Blood …, 2023 - ashpublications.org
Hematopoiesis produces diverse blood cell lineages to meet the basal needs and sudden
demands of injury or infection. A rapid response to such challenges requires the expansion …

The A to I editing landscape in melanoma and its relation to clinical outcome

A Amweg, M Tusup, P Cheng, E Picardi, R Dummer… - RNA biology, 2022 - Taylor & Francis
ABSTRACT RNA editing refers to non-transient RNA modifications that occur after
transcription and prior to translation by the ribosomes. RNA editing is more widespread in …

Biallelic ZBTB11 Variants: A Neurodevelopmental Condition with Progressive Complex Movement Disorders

JD Ortigoza‐Escobar, M Zamani, N Dorison… - Movement …, 2024 - Wiley Online Library
Background Biallelic ZBTB11 variants have previously been associated with an ultrarare
subtype of autosomal recessive intellectual developmental disorder (MRT69). Objective The …

A Combinatorial Regulatory Platform Determines Expression of RNA Polymerase III Subunit RPC7α (POLR3G) in Cancer

R Cheng, S Zhou, R KC, S Lizarazo, L Mouli, A Jayanth… - Cancers, 2023 - mdpi.com
Simple Summary The RNA polymerase III complex incorporates two forms of subunit RPC7:
RPC7α, which is highly abundant during early development, and RPC7β, the constitutive …