NUCLEAR receptor coregulators are coactivators or corepressors that are required by
nuclear receptors for efficient transcriptional regulation. In this context, we define …

Enhancers are important genomic regulatory elements directing cell type-specific
transcription. They assume a key role during development and disease, and their …

Candidate enhancers can be identified on the basis of chromatin modifications, the binding
of chromatin modifiers and transcription factors and cofactors, or chromatin accessibility …

The tumor suppressor p53 exerts antiproliferation effects through its ability to function as a
sequence-specific DNA-binding transcription factor. Here, we demonstrate that p53 can be …

Gene expression is regulated by promoters, which initiate transcription, and enhancers,
which control their temporal and spatial activity. However, the discovery that mammalian …

To elucidate the role of the synaptic protein α-synuclein in neurodegenerative disorders,
transgenic mice expressing wild-type human α-synuclein were generated. Neuronal …

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …

Steroid receptors and coactivator proteins are thought to stimulate gene expression by
facilitating the assembly of basal transcription factors into a stable preinitiation complex …

After integration in the host cell genome, the HIV‐1 provirus is packaged into chromatin. A
specific chromatin disruption occurs in the HIV‐1 promoter during transcriptional activation …

Steroid receptors bind to site-specific response elements in chromatin and modulate gene
expression in a hormone-dependent fashion. With the use of a tandem array of mouse …