Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …

Historically, the thalamus has been viewed as little more than a relay, simply transferring
information to key players of the cast, the cortex and hippocampus, without providing any …

The human brain is a complex, adaptive system comprised of billions of cells with trillions of
connections. The interactions between the elements of the system oppose this seemingly …

Standard models of episodic memory focus on hippocampal–parahippocampal interactions,
with the neocortex supplying sensory information and providing a final repository of …

In this review, we present a survey on Korsakoff's syndrome (KS), a residual syndrome in
patients who suffered from a Wernicke encephalopathy (WE) that is predominantly …

Interactions between the prefrontal cortex (PFC) and mediodorsal thalamus are critical for
cognitive flexibility, yet the underlying computations are unknown. To investigate …

The thalamus was subdivided into three major groups: sensorimotor nuclei (or
principal/relay nuclei), limbic nuclei and nuclei bridging these two domains. Limbic nuclei of …

Deficits in cognition are a core feature of many psychiatric conditions, including
schizophrenia, where the severity of such deficits is a strong predictor of long-term outcome …

Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral
flexibility. However, it remains unclear how a static, genetically controlled architecture …

Recent evidence from monkey models of cognition shows that the magnocellular
subdivision of the mediodorsal thalamus (MDmc) is more critical for learning new …