Elaborating on anti CTLA-4 mechanisms of action using an agent-based modeling approach
Anti CTLA-4 therapy is aimed at blocking the Cytotoxic T-lymphocyte antigen-4 (CTLA-4), a
key cancer immunity cycle checkpoint. The mechanism of action of CTLA-4 may be …
key cancer immunity cycle checkpoint. The mechanism of action of CTLA-4 may be …
Evaluation of Combination Strategies for the A2AR Inhibitor AZD4635 Across Tumor Microenvironment Conditions via a Systems Pharmacology Model
Background Adenosine receptor type 2 (A2AR) inhibitor, AZD4635, has been shown to
reduce immunosuppressive adenosine effects within the tumor microenvironment (TME) and …
reduce immunosuppressive adenosine effects within the tumor microenvironment (TME) and …