Hydrogen peroxide (H2O2) is a compound involved in some mammalian reactions and
processes. It modulates and signals the redox metabolism of cells by acting as a messenger …

Tumor cells harbor genetic alterations that promote a continuous and elevated production of
reactive oxygen species. Whereas such oxidative stress conditions would be harmful to …

Peroxiredoxins (Prxs) are a ubiquitous family of cysteine-dependent peroxidase enzymes
that play dominant roles in regulating peroxide levels within cells. These enzymes, often …

Mitochondrial reactive oxygen species (ROS) production is a tightly regulated redox signal
that transmits information from the organelle to the cell. Other mitochondrial signals, such as …

The cysteine (Cys) proteome is a major component of the adaptive interface between the
genome and the exposome. The thiol moiety of Cys undergoes a range of biologic …

A challenge in the redox field is the elucidation of the molecular mechanisms, by which H 2
O 2 mediates signal transduction in cells. This is relevant since redox pathways are …

Fungal response to any stress is intricate, specific, and multilayered, though it employs only
a few evolutionarily conserved regulators. This comes with the assumption that one …

Eukaryotic translation elongation factors 1 alpha, eEF1A1 and eEF1A2, are not only
translation factors but also pleiotropic proteins that are highly expressed in human tumors …

Hydrogen peroxide is widely viewed as the main second messenger in redox signaling, and
it has been proposed that deactivation of the antioxidant peroxiredoxin (Prdx) enzymes …

Regulation of protein function through thiol-based redox switches plays an important role in
the response and adaptation to local and global changes in the cellular levels of reactive …