Candida parapsilosis complex in the clinical setting

M Govrins, C Lass-Flörl - Nature Reviews Microbiology, 2024 - nature.com
Representatives of the Candida parapsilosis complex are important yeast species causing
human infections, including candidaemia as one of the leading diseases. This complex …

Galleria mellonella for the Evaluation of Antifungal Efficacy against Medically Important Fungi, a Narrative Review

S Jemel, J Guillot, K Kallel, F Botterel, E Dannaoui - Microorganisms, 2020 - mdpi.com
The treatment of invasive fungal infections remains challenging and the emergence of new
fungal pathogens as well as the development of resistance to the main antifungal drugs …

First report of candidemia clonal outbreak caused by emerging fluconazole-resistant Candida parapsilosis isolates harboring Y132F and/or Y132F+ K143R in Turkey

A Arastehfar, F Daneshnia… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Clonal outbreaks of fluconazole-resistant (FLZR) Candida parapsilosis isolates have been
reported in several countries. Despite its being the second leading cause of candidemia, the …

Determinants of fluconazole resistance and echinocandin tolerance in C. parapsilosis isolates causing a large clonal candidemia outbreak among COVID-19 patients …

F Daneshnia, JN de Almeida Júnior… - Emerging Microbes & …, 2022 - Taylor & Francis
Patients presenting with severe COVID-19 are predisposed to acquire secondary fungal
infections such as COVID-19-associated candidemia (CAC), which are associated with poor …

Recent gene selection and drug resistance underscore clinical adaptation across Candida species

MÀ Schikora-Tamarit, T Gabaldón - Nature Microbiology, 2024 - nature.com
Understanding how microbial pathogens adapt to treatments, humans and clinical
environments is key to infer mechanisms of virulence, transmission and drug resistance …

The CRISPR toolbox in medical mycology: State of the art and perspectives

F Morio, L Lombardi, G Butler - PLoS pathogens, 2020 - journals.plos.org
Fungal pathogens represent a major human threat affecting more than a billion people
worldwide. Invasive infections are on the rise, which is of considerable concern because …

Galleria mellonella Larvae as a Model for Investigating Fungal—Host Interactions

A Curtis, U Binder, K Kavanagh - Frontiers in Fungal Biology, 2022 - frontiersin.org
Galleria mellonella larvae have become a widely accepted and utilised infection model due
to the functional homology displayed between their immune response to infection and that …

CRISPR-Based Genetic Manipulation of Candida Species: Historical Perspectives and Current Approaches

D Uthayakumar, J Sharma, L Wensing… - Frontiers in Genome …, 2021 - frontiersin.org
The Candida genus encompasses a diverse group of ascomycete fungi that have captured
the attention of the scientific community, due to both their role in pathogenesis and emerging …

Evaluation of outbreak persistence caused by multidrug-resistant and echinocandin-resistant Candida parapsilosis using multidimensional experimental and …

F Daneshnia, DJ Floyd, AP Ryan… - Emerging Microbes & …, 2024 - Taylor & Francis
Candida parapsilosis is known to cause severe and persistent outbreaks in clinical settings.
Patients infected with multidrug-resistant C. parapsilosis (MDR Cp) isolates were identified …

Efficacy of LAMB against Emerging Azole- and Multidrug-Resistant Candida parapsilosis Isolates in the Galleria mellonella Model

U Binder, A Arastehfar, L Schnegg, C Hörtnagl… - Journal of Fungi, 2020 - mdpi.com
While being the third leading cause of candidemia worldwide, numerous studies have
shown severe clonal outbreaks due to fluconazole-resistant (FLCR) Candida parapsilosis …