Arterial hypertension–Clinical trials update 2021

H Al Ghorani, F Goetzinger, M Boehm… - Nutrition, Metabolism and …, 2022 - Elsevier
Aim This review aims to summarize and discuss some of the most relevant clinical trials in
epidemiology, diagnostics, and treatment of hypertension published in 2020 and 2021. Data …

Device-based therapies for arterial hypertension

L Lauder, M Azizi, AJ Kirtane, M Boehm… - Nature Reviews …, 2020 - nature.com
Arterial hypertension is the most prevalent modifiable risk factor associated with
cardiovascular morbidity and mortality. Although antihypertensive drugs are widely …

Ultrasound renal denervation for hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled …

M Azizi, K Sanghvi, M Saxena, P Gosse, JP Reilly… - The Lancet, 2021 - thelancet.com
Background Endovascular renal denervation reduces blood pressure in patients with mild-to-
moderate hypertension, but its efficacy in patients with true resistant hypertension has not …

Catheter-based ultrasound renal denervation in patients with resistant hypertension: the randomized, controlled REQUIRE trial

K Kario, Y Yokoi, K Okamura, M Fujihara… - Hypertension …, 2022 - nature.com
Renal denervation is a promising new non-pharmacological treatment for resistant
hypertension. However, there is a lack of data from Asian patients. The REQUIRE trial …

Impact of therapeutic lifestyle changes in resistant hypertension

C Ozemek, S Tiwari, A Sabbahi, S Carbone… - Progress in …, 2020 - Elsevier
Hypertensive individuals are at an increased risk of developing heart disease and stroke.
Adopting healthy lifestyles, such as being active on≥ 4 days per week, weight-loss in the …

European Society of Hypertension position paper on renal denervation 2021

RE Schmieder, F Mahfoud, G Mancia… - Journal of …, 2021 - journals.lww.com
Abstract This ESH Position Paper 2021 with updated proposed recommendations was
deemed necessary after the publication of a set of new pivotal sham-controlled randomized …

Proceedings from the 3rd European Clinical Consensus Conference for clinical trials in device-based hypertension therapies

F Mahfoud, M Azizi, S Ewen, A Pathak… - European heart …, 2020 - academic.oup.com
Proceedings from the 3rd European Clinical Consensus Conference for clinical trials in
device-based hypertension therapies | European Heart Journal | Oxford Academic Skip to Main …

Clinical trial design principles and outcomes definitions for device-based therapies for hypertension: a consensus document from the hypertension academic research …

DE Kandzari, F Mahfoud, MA Weber, R Townsend… - Circulation, 2022 - Am Heart Assoc
The clinical implications of hypertension in addition to a high prevalence of both
uncontrolled blood pressure and medication nonadherence promote interest in developing …

Effects of renal denervation vs sham in resistant hypertension after medication escalation: prespecified analysis at 6 months of the RADIANCE-HTN TRIO randomized …

M Azizi, F Mahfoud, MA Weber, ASP Sharp… - JAMA …, 2022 - jamanetwork.com
Importance Although early trials of endovascular renal denervation (RDN) for patients with
resistant hypertension (RHTN) reported inconsistent results, ultrasound RDN (uRDN) was …

Patient-level pooled analysis of ultrasound renal denervation in the sham-controlled RADIANCE II, RADIANCE-HTN SOLO, and RADIANCE-HTN TRIO trials

AJ Kirtane, ASP Sharp, F Mahfoud, NDL Fisher… - JAMA …, 2023 - jamanetwork.com
Importance Ultrasound renal denervation (uRDN) was shown to lower blood pressure (BP)
in patients with uncontrolled hypertension (HTN). Establishing the magnitude and …