Base-detecting pore

JA Clarke, L Jayasinghe, T Reid, JHP Bayley - US Patent 9,447,152, 2016 - Google Patents
US9447152B2 - Base-detecting pore - Google Patents US9447152B2 - Base-detecting pore -
Google Patents Base-detecting pore Download PDF Info Publication number US9447152B2 …

Up and down conversion systems for production of emitted light from various energy sources including radio frequency, microwave energy and magnetic induction …

FA Bourke Jr, Z Fathi, IN Stanton, MJ Therien… - US Patent …, 2016 - Google Patents
2011-01-31 Assigned to IMMUNOLIGHT, LLC, DUKE UNIVERSITY reassignment
IMMUNOLIGHT, LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …

Enzyme stalling method

AJ Heron, DA Alves, JA Clarke, ML Crawford… - US Patent …, 2019 - Google Patents
2015-10-15 Assigned to OXFORD NANOPORE TECHNOLOGIES LIMITED reassignment
OXFORD NANOPORE TECHNOLOGIES LIMITED ASSIGNMENT OF ASSIGNORS …

Mutant pores

J Clarke, AJ Heron, L Jayasinghe, EJ Wallace… - US Patent …, 2017 - Google Patents
US9751915B2 - Mutant pores - Google Patents US9751915B2 - Mutant pores - Google
Patents Mutant pores Download PDF Info Publication number US9751915B2 …

Method for sequencing a heteropolymeric target nucleic acid sequence

D Stoddart, AJ Heron, G Maglia, JHP Bayley - US Patent 9,732,381, 2017 - Google Patents
The invention relates to a method for sequencing a heteropolymeric target nucleic acid
sequence that involves stochastic sensing. The invention also relates to a method for …

Enzyme-pore constructs

L Jayasinghe, JHP Bayley, S Cheley… - US Patent …, 2018 - Google Patents
The invention relates to constructs comprising a transmem brane protein pore subunit and a
nucleic acid handling enzyme. The pore subunit is covalently attached to the enzyme such …

Methods of enhancing translocation of charged analytes through transmembrane protein pores

G Maglia, JHP Bayley - US Patent 9,562,887, 2017 - Google Patents
The invention relates to enhancing translocation of a charged analyte through a
transmembrane protein pore. Translocation is enhanced by increasing the net opposing …

Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores

CG Brown, JA Clarke, G Hall, G Harper… - US Patent …, 2018 - Google Patents
The invention relates to a new method of sequencing a double stranded target
polynucleotide. The two strands of the double stranded target polynucleotide are linked by a …

Hybridization linkers

L Jayasinghe, J Milton, L McNeill, JA Clarke… - US Patent …, 2015 - Google Patents
The invention provides method of covalently coupling two or more moieties, the method
comprising:(a) providing a first moiety having covalently attached thereto (i) at least one first …

Surface enhanced raman spectroscopy nanodome biosensors and methods of manufacturing the same

BT Cunningham, CJ Choi, AR Watkins - US Patent 8,953,159, 2015 - Google Patents
Tubing Such as clear plastic disposable tubing or glass tubing includes a photonic sensor
formed in or placed within the tubing. The photonic sensors can take the form of photonic …