Challenges of applying multicellular tumor spheroids in preclinical phase

SJ Han, S Kwon, KS Kim - Cancer cell international, 2021 - Springer
Abstract The three-dimensional (3D) multicellular tumor spheroids (MCTs) model is
becoming an essential tool in cancer research as it expresses an intermediate complexity …

[HTML][HTML] Therapeutic strategies of three-dimensional stem cell spheroids and organoids for tissue repair and regeneration

W Kim, Y Gwon, S Park, H Kim, J Kim - Bioactive Materials, 2023 - Elsevier
Abstract Three-dimensional (3D) stem cell culture systems have attracted considerable
attention as a way to better mimic the complex interactions between individual cells and the …

Spheroids as a type of three-dimensional cell cultures—examples of methods of preparation and the most important application

K Białkowska, P Komorowski, M Bryszewska… - International journal of …, 2020 - mdpi.com
Cell cultures are very important for testing materials and drugs, and in the examination of
cell biology and special cell mechanisms. The most popular models of cell culture are two …

3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

AS Nunes, AS Barros, EC Costa… - Biotechnology and …, 2019 - Wiley Online Library
Three‐dimensional cell culture models, such as spheroids, can be used in the process of the
development of new anticancer agents because they are able to closely mimic the main …

Strategies for 3D bioprinting of spheroids: A comprehensive review

D Banerjee, YP Singh, P Datta, V Ozbolat, A O'Donnell… - Biomaterials, 2022 - Elsevier
Biofabricated tissues have found numerous applications in tissue engineering and
regenerative medicine in addition to the promotion of disease modeling and drug …

Cell culture in microfluidic droplets

S Sart, G Ronteix, S Jain, G Amselem… - Chemical …, 2022 - ACS Publications
Cell manipulation in droplets has emerged as one of the great successes of microfluidic
technologies, with the development of single-cell screening. However, the droplet format has …

Advances in Spheroids and Organoids on a Chip

G Fang, YC Chen, H Lu, D Jin - Advanced Functional Materials, 2023 - Wiley Online Library
Multicellular spheroids and organoids are promising in vitro 3D models in personalized
medicine and drug screening. They replicate the structural and functional characteristics of …

Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures

J Dornhof, J Kieninger, H Muralidharan, J Maurer… - Lab on a Chip, 2022 - pubs.rsc.org
Three-dimensional cell cultures using patient-derived stem cells are essential in vitro
models for a more efficient and individualized cancer therapy. Currently, culture conditions …

[HTML][HTML] Core-shell microparticles: Generation approaches and applications

FM Galogahi, Y Zhu, H An, NT Nguyen - Journal of science: advanced …, 2020 - Elsevier
Micro-nanoscale core–shell particles are distinguishable from other particle types because
of their unique composition. Core-shell particles combine the features of both the core and …

Trends in droplet microfluidics: From droplet generation to biomedical applications

Z Chen, S Kheiri, EWK Young, E Kumacheva - Langmuir, 2022 - ACS Publications
Over the past decade, droplet microfluidics has attracted growing interest in biology,
medicine, and engineering. In this feature article, we review the advances in droplet …