Transient receptor potential (TRP) channels are a widely expressed family of 28
evolutionarily conserved cationic ion channels that operate as primary detectors of chemical …

Transient receptor potential cation channels subfamily V member 4 (TRPV4) are non-
selective cation channels expressed in different cell types of the central nervous system …

Introduction Astrocytic Aquaporin 4 (AQP4) and Transient receptor potential vanilloid 4
(TRPV4) channels form a functional complex that likely influences cell volume regulation …

The malignancy of glioblastoma (GBM), the most aggressive type of human brain tumor,
strongly correlates with the presence of hypoxic areas within the tumor mass. Oxygen levels …

Despite of the major role of aquaporin (AQP) water channels in controlling transmembrane
water fluxes, alternative ways for modulating water permeation have been proposed. In the …

In the adult brain, the water channel aquaporin‐4 (AQP4) is expressed in astrocyte endfoot,
in supramolecular assemblies, called “Orthogonal Arrays of Particles”(OAPs) together with …

Lysosomes are acidic Ca2+ storage organelles that actively generate local Ca2+ signaling
events to regulate a plethora of cell functions. Here, we characterized lysosomal Ca2+ …

Astrocytes, the main glial cells of the central nervous system, play a key role in brain volume
control due to their intimate contacts with cerebral blood vessels and the expression of a …

Brain edema is a pathological condition with potentially fatal consequences, related to
cerebral injuries such as ischemia, chronic renal failure, uremia, and diabetes, among …

We assessed interactions between the astrocytic volume-regulated anion channel (VRAC)
and aquaporin 4 (AQP4) in the supraoptic nucleus (SON). Acute SON slices and cultures of …