Cellular agriculture is an emerging branch of biotechnology that aims to address issues
associated with the environmental impact, animal welfare and sustainability challenges of …

Cultured meat is a bearer of hope for sustainable meat production, aiming at ensuring global
food security while preserving environmental resources. Being a nascent industry, there are …

After fertilization, the quiescent zygote experiences a burst of genome activation that initiates
a short-lived totipotent state. Understanding the process of totipotency in human cells would …

In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …

Trophoblasts are extraembryonic cells that are essential for maintaining pregnancy. Human
trophoblasts arise from the morula as trophectoderm (TE), which, after implantation …

Studies of cultured embryos have provided insights into human peri-implantation
development. However, detailed knowledge of peri-implantation lineage development as …

Understanding human development is of fundamental biological and clinical importance.
Despite its significance, mechanisms behind human embryogenesis remain largely …

Interspecies chimera formation with human pluripotent stem cells (hPSCs) represents a
necessary alternative to evaluate hPSC pluripotency in vivo and might constitute a …

The reprogramming of human somatic cells to primed or naive induced pluripotent stem
cells recapitulates the stages of early embryonic development,,,,–. The molecular …

Classic embryological experiments have established that the early mouse embryo develops
via sequential lineage bifurcations. The first segregated lineage is the trophectoderm …