Background The aim of this systematic review was (1) to identify the brain regions involved
in anxiety in Parkinson's disease (PD) based on neuroimaging studies and (2) to interpret …

Depression, anxiety and apathy are common mood disturbances in Parkinson's disease
(PD) but their pathophysiology is unclear. Advanced neuroimaging has been increasingly …

Background The variability in the clinical phenotype of Parkinson's disease seems to
suggest the existence of several subtypes of the disease. To test this hypothesis we …

Dopamine transporter (DAT) single-photon emission tomography (SPECT) with (123)
Ioflupane is a widely used diagnostic tool for patients with suspected parkinsonian …

Parkinson's disease (PD) pathology is characterized by the formation of intra-neuronal
inclusions called Lewy bodies, which are comprised of alpha-synuclein (α-syn). Duplication …

Synucleinopathies are neurodegenerative disorders characterized by alpha-synuclein
(αSyn) accumulation in neurons or glial cells, including Parkinson's disease (PD), dementia …

Apathy, depression, and anxiety are among the most important non-motor signs of
Parkinson's disease (PD). This may be encountered at early stages of illness and represent …

Anxiety is common in Parkinson's disease (PD), and contributes to increased disability and
poorer quality of life. In spite of its significant impact, the symptomatology, chronology, and …

Background Excessive daytime sleepiness (EDS) is common and disabling in Parkinson's
disease (PD). Predictors of EDS are unclear, and data on biological correlates of EDS in PD …

Neuropsychiatric symptoms are common and disabling in PD. Their neurobiological bases
are complex, partly because of the disease itself and partly because of the dopaminergic …