Iminosugars, featuring a basic nitrogen at the hetero atom position in carbohydrate rings,
gain increasing interest in the search for novel approaches towards cancer drug …

The principal methods for the synthesis of pyrrolizidine and indolizidine alkaloids and their
unnatural analogs are described. Six main “strategic” approaches in regard to a key step …

Covering: 2005 to the end of 2009 In addition to their clinical importance in the treatment of
type II diabetes, α-glucosidase inhibitors have attracted considerable attention from the …

This review of simple indolizidine and quinolizidine alkaloids (ie, those in which the parent
bicyclic systems are in general not embedded in polycyclic arrays) is an update of the …

Azidation of 1, 2-anhydro sugars with NaN3 in CH3CN by using a catalytic amount of ceric
ammonium nitrate has been accomplished in a regio-and stereoselective manner. Various …

The asymmetric total synthesis of the α-glucosidase inhibitor (+)-castanospermine is
reported. The central theme in our approach to this polyhydroxylated alkaloid is the …

This personal account focuses on synthesis of polyhydroxylated piperidines, a subset of
compounds within the iminosugar family. Cyclisations to form the piperidine ring include …

The diastereoselective synthesis of castanospermine is described in 11 synthetic steps from
l-xylose. The borono-Mannich reaction between l-xylose, allylamine, and (E)-styrene boronic …

The intramolecular aminomercuration reaction of sugar-derived β-hydroxy-γ-alkenylamines
8a− c undergoes 5-endo-trig cyclization in high yield. The sugar-substituted pyrrolidines …

A nine-step synthesis of (+)-castanospermine has been accomplished in 22% overall yield
from methyl α-d-glucopyranoside. The key transformations involve a zinc-mediated …