Azoospermia due to obstructive and non-obstructive mechanisms is a common
manifestation of male infertility accounting for 10-15% of such cases. Known genetic factors …

Maintaining the integrity of sperm DNA is vital to reproduction and male fertility. Sperm
contain a number of molecules and pathways for the repair of base excision, base …

In the testis, cell adhesion and junctional molecules permit specific interactions and
intracellular communication between germ and Sertoli cells and apposed Sertoli cells …

During the last phase of spermatogenesis, spermiogenesis, haploid round spermatids
metamorphose towards spermatozoa. Extensive cytoplasmic reduction and chromatin …

Background Poly (ADP-ribose) polymerase (PARP) inhibitors represent a new class of
promising drugs in anticancer therapy. Aims To evaluate PARP expression in testicular germ …

This special issue is fully dedicated to the topic of azoospermia and contains the seminal
work of renowned scientists and clinicians from seven countries on three continents. In …

The repair of DNA double strand breaks (DSBs) in male germ cells is slower and differently
regulated compared to that in somatic cells. Round spermatids show DSB repair and are …

The wide occurrence of male infertility is a matter of grave concern. One of the major causes
being exposure to endocrine disrupting chemicals (EDCs) many of which are known …

Spermatids are extremely sensitive to genotoxic exposures since during spermiogenesis
only error-prone non homologous end joining (NHEJ) repair pathways are available. Hence …

ADP-ribosylation is an evolutionarily conserved complex posttranslational modification that
alters protein function and/or interaction. Intracellularly, it is mainly catalyzed by diphtheria …