Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …

Spinal cord injury is a severely disabling neurological condition leading to impaired mobility,
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …

Neural stem cells (NSCs) generate new neurons throughout life in the mammalian brain.
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …

In vitro cell cultures are crucial research tools for modeling human development and
diseases. Although the conventional monolayer cell cultures have been widely used in the …

In the adult rodent brain, neural stem cells (NSCs) persist in the ventricular-subventricular
zone (V-SVZ) and the subgranular zone (SGZ), which are specialized niches in which young …

Although the neurogenesis-enhancing effects of exercise have been extensively studied, the
molecular mechanisms underlying this response remain unclear. Here, we propose that this …

In previous years, three‑dimensional (3D) cell culture technology has become a focus of
research in tumor cell biology, using a variety of methods and materials to mimic the in vivo …

Adult somatic stem cells in various organs maintain homeostatic tissue regeneration and
enhance plasticity. Since its initial discovery five decades ago, investigations of adult …

Abstract TGF-β 1–3 are unique multi-functional growth factors that are only expressed in
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …

Recently, many types of in vitro 3‐D culture systems have been developed to recapitulate
the in vivo growth conditions of cancer. The cancer 3‐D culture methods aim to preserve the …