The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Lipid and immune pathways are crucial in the pathophysiology of metabolic and
cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to …

Arachidonic acid (AA) is an essential fatty acid that is released by phospholipids in cell
membranes and metabolized by cyclooxygenase (COX), cytochrome P450 (CYP) enzymes …

Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …

Doxorubicin (DOX) is a wide spectrum antitumor drug, but its clinical application is limited by
the cardiotoxicity. Ghrelin, a multi-functional peptide hormone with metabolic regulation in …

SIRT6, a member of the NAD (+)-dependent class III deacetylase sirtuin family, has been
revealed to play important roles in promoting cellular resistance against oxidative stress …

Acute coronary syndrome (ACS) is a set of signs and symptoms caused by a reduction of
coronary blood flow with subsequent myocardial ischemia. ACS is associated with activation …

Abstract Leukotrienes (LTs) derived from 5-lipoxygenase (5-LO) activity are most widely
known for their actions during acute inflammation and asthma. 5-LO/LT pathway …

Cysteinyl leukotrienes (cysLTs), leukotriene C4 (LTC4), LTD4, and LTE4 are
proinflammatory lipid mediators with pathobiologic function in asthma. LTE4, the stable …

The leukotrienes are important lipid mediators with immune modulatory and proinflammatory
properties. Classical bioactions of leukotrienes include chemotaxis, endothelial adherence …