GABAA (γ-aminobutyric acid, type A) receptors are a family of ligand-gated ion channels that
are essential for the regulation of central nervous system function. Benzodiazepines—which …

Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors or GABAkines
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …

GABA A receptors are the major inhibitory transmitter receptors in the brain. They are ligand-
gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive …

This mini-review attempts to update experimental evidence on the existence of GABAA
receptor pharmacological subtypes and to produce a list of those native receptors that exist …

Benzodiazepines are widely used clinically to treat anxiety and insomnia. They also induce
muscle relaxation, control epileptic seizures, and can produce amnesia. Moreover …

Ion channels are membrane proteins expressed in almost all living cells. The sequencing of
the human genome has identified more than 400 putative ion channels, but only a fraction of …

Despite decades of basic and clinical research, our understanding of how benzodiazepines
tend to lose their efficacy over time (tolerance) is at least incomplete. In appears that …

Schizophrenia is a brain disorder associated with cognitive deficits that severely affect the
patients′ capacity for daily functioning. Whereas our understanding of its pathophysiology …

Over the past several decades, benzodiazepines and the newer non-benzodiazepines have
become the anxiolytic/hypnotics of choice over the more readily abused barbiturates. While …