Eicosanoids are biologically active lipid mediators, comprising prostaglandins, leukotrienes,
thromboxanes, and lipoxins, involved in several pathophysiological processes relevant to …

The field of pharmacogenetics, the investigation of the influence of one or more sequence
variants on drug response phenotypes, is a special case of pharmacogenomics, a discipline …

Background To date, genetic studies of hypersensitivity reactions to non‐steroidal anti‐
inflammatory drugs (NSAID s) have been carried out mainly in aspirin‐induced asthma and …

ABSTRACT Prostaglandin D2 (PGD2) is one of the most abundant lipid mediators present in
the airways of asthmatics. However, little was known of the role it plays in the …

To cite this article: Isidoro‐García M, Sanz C, García‐Solaesa V, Pascual M, Pescador DB,
Lorente F, Dávila I. PTGDR gene in asthma: a functional, genetic, and epigenetic study …

Pharmacogenetics investigates the influence of genetic variants on physiological
phenotypes related to drug response and disease, while pharmacogenomics takes a …

BACKGROUND: Prostaglandin D2 is a proinflammatory mediator believed to be important in
asthma and allergic rhinitis (AR). Allelic variants in the prostaglandin D2 receptor type 1 …

■ Abstract Background and Objectives: Nasal polyposis (NP) is a chronic inflammatory
disease of the upper airways with a variable clinical course and unknown pathogenesis that …

Background: Asthma is a heterogeneous syndrome with a broad clinical spectrum and high
drug response variability. The inflammatory response in asthma involves multiple effector …

[EN] Nitric Oxide (NO) has been proposed as an important signaling molecule. NO produced
by the inducible NO synthase enzyme NOS2A is generated at high levels in certain types of …