The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

Krüppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with
diverse and essential functions in a multitude of cellular processes, including proliferation …

Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested
that KLF5 regulates the expression of a large number of new target genes and participates …

Advanced prostate cancer (PCa) often develops bone metastasis, for which therapies are
very limited and the underlying mechanisms are poorly understood. We report that bone …

Transforming growth factor beta (TGF-β) is a multi-functional polypeptide that plays a critical
role in regulating a broad range of cellular functions and physiological processes. Signaling …

The evasion of anti-growth signaling is an important characteristic of cancer cells. In order to
continue to proliferate, cancer cells must somehow uncouple themselves from the many …

Inactivation of phosphatase and tensin homolog (PTEN) is prevalent in human prostate
cancer and causes high-grade adenocarcinoma with a long latency. Cancer-associated …

The Yes-associated protein (YAP), an oncoprotein in the Hippo tumor suppressor pathway,
regulates tumorigenesis and has been found in a variety of tumors, including breast …

Despite the development of cancer therapies, the success of most treatments has been
impeded by drug resistance. The crucial role of tumor cell plasticity has emerged recently in …

FOXO transcription factors control proliferation, apoptosis, differentiation and metabolic
processes. Loss of FOXO function has been identified in several human cancers, and results …