Nicotine and alcohol are two of the most commonly abused legal substances. Heavy use of
one drug can often lead to, or is predictive of, heavy use of the other drug in adolescents and …

Studies from several laboratories have shown that ethanol impairs cerebellar function, in
part, by altering GABAergic transmission. Here, we discuss recent advances in our …

The cerebellum is an important target of ethanol toxicity given that cerebellar ataxia is the
most consistent physical manifestation of acute ethanol consumption. Despite the …

Previous findings have demonstrated that variants in nicotinic receptor genes are associated
with nicotine, alcohol and cocaine dependence. Because of the substantial comorbidity, it …

While the co-morbidity of alcohol (ethanol) and tobacco (nicotine) dependence is well
described, the processes that underpin this strong connection are still under debate. With …

The cholinergic system is a neuromodulatory neurotransmitter system involved in a variety of
brain processes, including learning and memory, attention, and motor processes, among …

Abstract Background Angiotensin II (Ang II) in the local cardiac renin-angiotensin system
(RAS) is closely associated with alcoholic cardiomyopathy (ACM). Inhibition of local cardiac …

Abstract Choline acetyltransferase-positive (ChAT+) neurons within the subventricular zone
(SVZ) have been shown to promote neurogenesis after stroke in mice by secreting …

Clinical studies have reported that the nicotinic receptor agonist varenicline improves
balance and coordination in patients with several types of ataxia, but confirmation in an …

There is a strong association between tobacco smoking and the consumption of alcoholic
beverages. When compared to the effects of either drug on its own, the combined use may …