Ribosomal proteins are synthesized in the cytoplasm, before nuclear import and assembly
with ribosomal RNA (rRNA). Little is known about coordination of nucleocytoplasmic …

The assembly of eukaryotic ribosomes is a hierarchical process involving about 200
biogenesis factors and a series of remodeling steps. The 5S RNP consisting of the 5S rRNA …

Co-translational protein targeting to membranes relies on the signal recognition particle
(SRP) system consisting of a cytosolic ribonucleoprotein complex and its membrane …

Co-translational protein targeting to membranes depends on the regulated interaction of two
ribonucleoprotein particles (RNPs): the ribosome and the signal recognition particle (SRP) …

The signal recognition particle (SRP) is a ribonucleoprotein complex with a key role in
targeting and insertion of membrane proteins. The two SRP GTPases, SRP54 (Ffh in …

Archaea SRP is composed of an SRP RNA molecule and two bound proteins named SRP19
and SRP54. Regulated by the binding and hydrolysis of guanosine triphosphates, the RNA …

Co-translational protein targeting and membrane protein insertion is a fundamental process
and depends on the signal recognition particle (SRP). In mammals, SRP is composed of the …

The signal recognition particle (SRP) is central to membrane protein targeting; SRP RNA is
essential for SRP assembly, elongation arrest, and activation of SRP guanosine …

The Alu domain of the signal recognition particle (SRP) arrests protein biosynthesis by
competition with elongation factor binding on the ribosome. The mammalian Alu domain is a …

Cell viability is only possible due to a dynamic range of essential nucleic acid-protein
complex formation. DNA replication and repair, gene expression, transcription and protein …