Rheumatoid arthritis (RA) is an inflammatory disease typically affecting the joints, but the
systemic inflammatory process may involve other tissues and organs. Many extra-articular …

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease involving symmetric joints
and is generally characterized by persistent pain, tenderness, and destruction of joints. The …

Despite nearly three decades of advances in the management of rheumatoid arthritis (RA), a
substantial minority of patients are exposed to multiple DMARDs without necessarily …

Rheumatoid arthritis (RA) is a systemic auto-immune disease principally effecting synovial
joints. RA is characterized by immune cell infiltration in the joint. The presence of …

Interstitial lung disease (ILD) is an increasingly recognized complication of rheumatoid
arthritis (RA) and is associated with significant morbidity and mortality. In addition …

In this Review we focus on the initiation of autoantibody production and autoantibody
pathogenicity, with a special emphasis on the targeted antigens. Release of intracellular …

Background Rheumatoid arthritis is a chronic inflammatory disease with a substantial
genetic component. Susceptibility to disease has been linked with a region on chromosome …

Background Rheumatoid arthritis has a complex mode of inheritance. Although HLA-DRB1
and PTPN22 are well-established susceptibility loci, other genes that confer a modest level …

Antibodies to citrullinated proteins (ACPA), ie, to peptides posttranslationally modified by the
conversion of arginine to citrulline, are specific serological markers for rheumatoid arthritis …

Background Rheumatoid arthritis (RA) can be divided into two major subsets based on the
presence or absence of antibodies to citrullinated peptide antigens (ACPA). Until now, data …