Obesity, a social problem worldwide, is characterized by an increase in body weight that
results in excessive fat accumulation. Obesity is a major cause of morbidity and mortality and …

Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in
longevity and age‐related metabolic dysfunction. Fat distribution and function change …

Obesity plays a causative role in the pathogenesis of the metabolic syndrome. Adipokines
may link obesity to its co-morbidities. Most adipokines with pro-inflammatory properties are …

Chronic, systemic inflammation is an independent risk factor for several major clinical
diseases. In obesity, circulating levels of inflammatory markers are elevated, possibly due to …

Endothelial dysfunction is a well established response to cardiovascular risk factors and
precedes the development of atherosclerosis. Endothelial dysfunction is involved in lesion …

Background—Visceral fat is a key regulator site for the process of inflammation, and
atherosclerotic lesions are essentially an inflammatory response. Methods and Results …

The molecular mechanisms by which extreme blood pressure elevation leads to vascular
injury are not defined. To explore the hypothesis that activation of endothelium and platelets …

Background—Inflammatory processes have fundamental roles in stroke in both the etiology
of ischemic cerebrovascular disease and the pathophysiology of cerebral ischemia. We …

Obesity has been suggested to be a low-grade systemic inflammatory state, therefore we
studied the interaction between human adipocytes and monocytes via adipose tissue (AT) …

Endothelial dysfunction is a key event in cardiovascular disease. Measurement of
endothelial dysfunction in vivo presents a major challenge, but has important implications …