Gliomas are primary brain tumours that are thought to derive from neuroglial stem or
progenitor cells. On the basis of their histological appearance, they have been traditionally …

Surgical resection remains the mainstay of treatment for patients with glioma of any grade.
Maximal resection of the tumour is central to achieving long-term disease control; however …

Brain tumors represent the second most frequent etiology in patients with focal seizure onset
before 18 years of age and submitted to epilepsy surgery. Hence, this category of brain …

Astrocytes are key active elements of the brain that contribute to information processing.
They not only provide neurons with metabolic and structural support, but also regulate …

Diffuse low-grade glioma grows, migrates along white matter tracts, and progresses to high-
grade glioma. Rather than a “wait and see” policy, an aggressive attitude is now …

Background Total or subtotal surgical resection of WHO grade II glioma (diffuse low-grade
glioma, DLGG) can significantly increase survival. Moreover, a supratotal resection, ie, an …

Epilepsy often develops in patients with glioma, and the two conditions share common
pathogenic mechanisms. Altered expression of glutamate transporters, including the cystine …

Brain tumor-related epilepsy (BTE) is common in low-and high-grade gliomas. The risk of
seizures varies between 60% and 100% among low-grade gliomas and between 40% and …

Brain gliomas are highly epileptogenic. Excitatory glutamatergic mechanisms are involved in
the generation of epileptic activities in the neocortex surrounding gliomas. However …

Onset of many forms of epilepsy occurs after an initial epileptogenic insult or as a result of an
identified genetic defect. Given that the precipitating insult is known, these epilepsies are, in …