Angiogenesis is a process associated with the migration and proliferation of endothelial
cells (EC) to form new blood vessels. It is involved in various physiological and …

Simple Summary The tumor microenvironment plays an important role in determining the
biological behavior of several of the more aggressive malignancies. Among the various cell …

SARS-CoV-2 vaccinations have greatly reduced COVID-19 cases, but we must continue to
develop our understanding of the nature of the disease and its effects on human immunity …

The serine protease inhibitor clade E member 1 (SERPINE1) is a major inhibitor of tissue
plasminogen activator and urokinase, and has been implicated in the development and …

Inflammation is an essential component of several respiratory diseases, such as chronic
obstructive pulmonary disease (COPD), asthma and acute respiratory distress syndrome …

Background The tumor microenvironment (TME) has been shown to strongly influence
treatment outcome for cancer patients in various indications and to influence the overall …

The incidence of obesity and colorectal cancer (CRC) has risen rapidly in recent decades.
More than 650 million obese and 2 billion overweight individuals are currently living in the …

Melanoma is one of the seven most common cancers in the United States, and its incidence
is still increasing. Since 2011, developments in targeted therapies and immunotherapies …

PAI-1 plays significant roles in cancer occurrence, relapse and multidrug resistance and is
highly expressed in tumours. ACT001, which is currently in phase I clinical trials for the …

Although accumulating evidence indicates that alternative splicing is aberrantly altered in
many cancers, the functional mechanism remains to be elucidated. Here, we show that …