Mesenchymal stem cells and immunomodulation: current status and future prospects

F Gao, SM Chiu, DAL Motan, Z Zhang, L Chen… - Cell death & …, 2016 - nature.com
The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them
an invaluable cell type for the repair of tissue/organ damage caused by chronic inflammation …

Stem cells and regenerative medicine: myth or reality of the 21th century

JF Stoltz, N de Isla, YP Li, D Bensoussan… - Stem cells …, 2015 - Wiley Online Library
Since the 1960s and the therapeutic use of hematopoietic stem cells of bone marrow origin,
there has been an increasing interest in the study of undifferentiated progenitors that have …

Lipopolysaccharide‐induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo

S Nair, KS Sobotka, P Joshi, P Gressens, B Fleiss… - Glia, 2019 - Wiley Online Library
Accumulating evidence suggests that changes in the metabolic signature of microglia
underlie their response to inflammation. We sought to increase our knowledge of how pro …

[HTML][HTML] Bioenergetic crosstalk between mesenchymal stem cells and various ocular cells through the intercellular trafficking of mitochondria

D Jiang, FX Chen, H Zhou, YY Lu, H Tan, SJ Yu… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Mitochondrial disorders preferentially affect tissues with high energy
requirements, such as the retina and corneal endothelium, in human eyes. Mesenchymal …

Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage

D Jiang, F Gao, Y Zhang, DSH Wong, Q Li, H Tse… - Cell death & …, 2016 - nature.com
Recent studies have demonstrated that mesenchymal stem cells (MSCs) can donate
mitochondria to airway epithelial cells and rescue mitochondrial damage in lung injury. We …

Mitochondrial transfer of induced pluripotent stem cell–derived mesenchymal stem cells to airway epithelial cells attenuates cigarette smoke–induced damage

X Li, Y Zhang, SC Yeung, Y Liang, X Liang… - American journal of …, 2014 - atsjournals.org
Transplantation of mesenchymal stem cells (MSCs) holds great promise in the repair of
cigarette smoke (CS)-induced lung damage in chronic obstructive pulmonary disease …

Autophagy promotes MSC-mediated vascularization in cutaneous wound healing via regulation of VEGF secretion

Y An, WJ Liu, P Xue, Y Ma, LQ Zhang, B Zhu, M Qi… - Cell death & …, 2018 - nature.com
Vascularization deficiency caused a lot of diseases, such as diabetes ulcer and myocardial
infarction. Mesenchymal stem cells (MSCs), with the self-renewal and multipotent …

Human pluripotent stem cell-derived mesenchymal stem cells prevent allergic airway inflammation in mice

YQ Sun, MX Deng, J He, QX Zeng, W Wen… - Stem …, 2012 - academic.oup.com
We previously found that mesenchymal stem cells (MSCs) derived from human-induced
pluripotent stem cells (iPSCs) exerted immunomodulatory effects on Th2-mediated allergic …

Mesenchymal stem cells alleviate oxidative stress–induced mitochondrial dysfunction in the airways

X Li, C Michaeloudes, Y Zhang, CH Wiegman… - Journal of Allergy and …, 2018 - Elsevier
Background Oxidative stress–induced mitochondrial dysfunction can contribute to
inflammation and remodeling in patients with chronic obstructive pulmonary disease …

Concise review: mesenchymal stem cells derived from human pluripotent cells, an unlimited and quality-controllable source for therapeutic applications

B Jiang, L Yan, X Wang, E Li, K Murphy, K Vaccaro… - Stem …, 2019 - academic.oup.com
Despite the long discrepancy over their definition, heterogeneity, and functions,
mesenchymal stem cells (MSCs) have proved to be a key player in tissue repair and …