Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan
(CSPG)-containing structures that surround the soma and dendrites of various mammalian …

Microglia shape the synaptic environment in health and disease, but synapses do not exist
in a vacuum. Instead, pre-and postsynaptic terminals are surrounded by extracellular matrix …

During restricted time windows of postnatal life, called critical periods, neural circuits are
highly plastic and are shaped by environmental stimuli. In several mammalian brain areas …

Perineuronal nets (PNNs) are specialized extracellular matrix structures that surround
specific neurons in the brain and spinal cord, appear during critical periods of development …

Background The extracellular matrix (ECM) of the brain is rich in glycosaminoglycans such
as chondroitin sulfate (CS) and hyaluronan. These glycosaminoglycans are organized into …

Perineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular
matrix structures with heterogeneous composition yet specific organization. They typically …

In Alzheimer's disease (AD), different types of neurons and different brain areas show
differential patterns of vulnerability towards neurofibrillary degeneration, which provides the …

Synapses are specialized structures that mediate rapid and efficient signal transmission
between neurons and are surrounded by glial cells. Astrocytes develop an intimate …

Chondroitin sulfate proteoglycans (CSPGs) are involved in several processes relevant to
recovery of function after CNS damage. They restrict axon regeneration through their …

Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that surround
the soma and proximal dendrites of certain neurons in the central nervous system …