Hypoxia is a pathological condition arising in living tissues when oxygen supply does not
adequately cover the cellular metabolic demand. Detection of this phenomenon in tumors is …

Copper-64 (T1/2= 12.7 h) is a positron and beta-emitting isotope, with decay characteristics
suitable for both positron emission tomography (PET) imaging and radiotherapy of cancer …

Thiosemicarbazones and their metal complexes are compounds that possess antitumor,
antibacterial, antifungal and antiviral properties. For the foremost majority of cases the …

Abstract Radioactive copper (II)(diacetyl-bis N4-methylthiosemicarbazone)(Cu-ATSM)
isotopes were originally developed for the imaging of hypoxia in tumors. Because the decay …

PET imaging has gained significant momentum in the last few years, especially in the area
of oncology, with an increasing focus on metal radioisotopes owing to their versatile …

Tumors exhibit areas of decreased oxygenation due to malformed blood vessels. This low
oxygen concentration decreases the effectiveness of radiation therapy, and the resulting …

Hypoxia plays a critical role in tumor development and aggressiveness and is an important
prognostic factor for resistance to antineoplastic treatments; therefore, it is required to …

Purpose 64Cu-diacetyl-bis (N 4-methylthiosemicarbazone)(64Cu-ATSM) is a promising
theranostic agent that targets hypoxic regions in tumors related to malignant characteristics …

During past 3 decades, nuclear medicine has flourished as vibrant and independent
medical specialty in Iran. Since that time, more than 200 nuclear physicians have been …

Following our previous work on the production of radiometals, such as 64Cu and 68Ga,
through the irradiation of liquid targets using a medical cyclotron, we describe in this paper a …