Abstract Zinc (Zn 2+) is an essential element crucial for growth and development, and also
plays a role in cell signaling for cellular processes like cell division and apoptosis. In the …

Mechanisms controlling transcription and its regulation are fundamental to our
understanding of molecular biology and, ultimately, cellular biology. Our knowledge of …

In vivo protein-DNA interactions connect each transcription factor with its direct targets to
form a gene network scaffold. To map these protein-DNA interactions comprehensively …

Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic beta cells are killed by
infiltrating immune cells and by cytokines released by these cells. Signaling events …

Tissue-specific transcriptional regulation is central to human disease. To identify regulatory
DNA active in human pancreatic islets, we profiled chromatin by formaldehyde-assisted …

Aims/hypothesis Pancreatic islet beta cell failure causes type 2 diabetes in humans. To
identify transcriptomic changes in type 2 diabetic islets, the Innovative Medicines Initiative for …

Neonatal diabetes is caused by single gene mutations reducing pancreatic β cell number or
impairing β cell function. Understanding the genetic basis of rare diabetes subtypes …

Recent genome-wide association studies (GWAS) have identified DNA sequence variations
that exhibit unequivocal statistical associations with many common chronic diseases …

We demonstrate that the histone deacetylase (HDAC) inhibitor drug trichostatin A (TSA)
reduces spinal cord inflammation, demyelination, neuronal and axonal loss and ameliorates …

Abstract Transient (TNDM) and Permanent (PNDM) Neonatal Diabetes Mellitus are rare
conditions occurring in 1: 300,000–400,000 live births. TNDM infants develop diabetes in …